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diagnostic value

At the same time, various gynecological diseases may appear identical to the character of the same type of bleeding and menstrual irregularities. For example, spotting from the genital tract shortly before menstruation or soon thereafter due to internal endometriosis of the uterus, endometrial polyp, chronic endometritis.
Below is for the reader MirSovetov a table, which reflects the most common diseases and symptoms.

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Paradoxically, the intensity of bleeding itself is rarely of great importance in the diagnosis, but it certainly is one of the most important factors determining the need for emergency assistance. In fact, and dysfunctional haemorrhage, and, for example, hemorrhage in cancer or incomplete abortion may be equally profuse and abundant and scarce.
However, the approval of a small diagnostic value of information about the intensity of bleeding can not be understood in such a way that this figure does not pay attention. For example, it is well known that one of the main symptoms of tubal pregnancy, broken by the type of tubal abortion is the availability of scarce discharge, whereas in the uterine myoma they can be very abundant.

primary endpoint

Pharmaceutical companies Eisai, which specializes in drugs for the treatment of neurological diseases, diseases of the gastrointestinal tract cancers, as well as in the production of drugs for intensive care and resuscitation, filed an application for registration Eribulin mesylate (netaksanovy inhibitor of microtubule dynamics) in Japan, the U.S. and the EU. The company expects to receive approval of the drug for the treatment of locally advanced or metastatic cancer of the breast.


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According to Eisai, the application is based primarily on data from the main international phase III EMBRACE (Eisai Metastatic Breast Cancer Study Assessing Physician's Choice Versus E7389). This was an open, randomized parallel in the two groups multicenter study involving 762 women with locally recurrent or metastatic breast cancer that have passed at least two courses of chemotherapy (anthracycline and taxanes).
During the study, patients received either intravenous Eribulin 2-5 minutes for 1 st and 8 th day every 21 days or received another treatment at the option of a doctor.



The study achieved the primary endpoint - was demonstrated statistically significant increase in overall survival in patients receiving Eribulin, compared with patients who were treated at the choice of doctor.